IRIG: O-GlcNAc and PGC-1 in Nature
03/09/2008 21:20
The negative-feedback loop in the insulin signaling
pathway is a framework for the concept of
post-receptor signaling defect theory, which
represents the mainstream views of insulin
resistance. In the school, inhibition of insulin
receptor substrates (IRSs) by serine/threonine
kinases is the core. Many molecular hypotheses for
insulin resistance, such as inflammation, ER stress,
mitochondrial dysfunction, oxidative stress,
hyperinsulinemia, and hypoadiponectinemia, are built
on the core. A new study in Nature enriched the
theory by demonstration that insulin may promote
IRS-1 inhibition by increasing glycocylation of
IRS-1. The enzyme O-GlcNAc transferase (OGT) mediates
this activity of insulin. This paper is recommended
by Dr. Marina Bouché at the University of Rome,
Italy. (See PDF file
attached).
PGC-1a is another “star” molecule like SIRT1. PGC-1a is a transcription coactivator originally identified in the study of PPARg. PGC-1a is involved in glucose homeostasis, mitochondrial biogenesis, circadian rhythm, and energy expenditure. A new study in Nature shows that PGC-1a is involved in protection of microcirculation from ischemia damage by promoting angiogenesis. The mechanism is induction of VEGF expression by PGC-1a. (See PDF file attached).
By the way, the “Insight” section of Nature is focused on Cardiovascular disease in this issue. It contains eight excellent reviews about different aspects of CVDs. Here is the link: http://www.nature.com/nature/index.html
By Jianping at PBRC
-----------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763-3163
E-mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
PGC-1a is another “star” molecule like SIRT1. PGC-1a is a transcription coactivator originally identified in the study of PPARg. PGC-1a is involved in glucose homeostasis, mitochondrial biogenesis, circadian rhythm, and energy expenditure. A new study in Nature shows that PGC-1a is involved in protection of microcirculation from ischemia damage by promoting angiogenesis. The mechanism is induction of VEGF expression by PGC-1a. (See PDF file attached).
By the way, the “Insight” section of Nature is focused on Cardiovascular disease in this issue. It contains eight excellent reviews about different aspects of CVDs. Here is the link: http://www.nature.com/nature/index.html
By Jianping at PBRC
-----------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763-3163
E-mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
|