IRIG: Brown fat in Human
04/20/2009 12:18
Brown fat is known to
produce heat for maintenance of the body
temperature in rodents. Brown adipocytes have a high density of
mitochondria thus make it "brown" in color. Mitochondria in brown
adipocytes are unique in that it oxidizes fatty acid and glucose to
generate heat, not ATP. This feature is due to expression of uncoupling
protein 1 (UCP‑1) that prevents ATP production in the mitochondria. It
has been controversial about existence and function of brown fat in
human. Now, this issue is resolved by three papers in the New England
Journal of Medicine. In these studies, it was found that human body does
have brown fat, but not every body have it. It is found in 7.5% of Women
and 3.5% of man. It produces heat in response to cold environment in
healthy man. It's mass is reduced in obese condition. See attached PDF
files of the three papers and a mini review. These papers are
recommended by Dr. Eugene Chen at the University of Michigan.
Brown fat minireview
Brown fat in healthy adults
Brown fat in healthy men
Brown fat in men and women
Regards,
By Jianping at PBRC/LSU
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763‑3163
E‑mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
temperature in rodents. Brown adipocytes have a high density of
mitochondria thus make it "brown" in color. Mitochondria in brown
adipocytes are unique in that it oxidizes fatty acid and glucose to
generate heat, not ATP. This feature is due to expression of uncoupling
protein 1 (UCP‑1) that prevents ATP production in the mitochondria. It
has been controversial about existence and function of brown fat in
human. Now, this issue is resolved by three papers in the New England
Journal of Medicine. In these studies, it was found that human body does
have brown fat, but not every body have it. It is found in 7.5% of Women
and 3.5% of man. It produces heat in response to cold environment in
healthy man. It's mass is reduced in obese condition. See attached PDF
files of the three papers and a mini review. These papers are
recommended by Dr. Eugene Chen at the University of Michigan.
Brown fat minireview
Brown fat in healthy adults
Brown fat in healthy men
Brown fat in men and women
Regards,
By Jianping at PBRC/LSU
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763‑3163
E‑mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
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