Following are interesting papers in JAMA and JCI for glucose and fat metabolism.

By Jianping at PBRC
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Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial

Leonie K. Heilbronn, Lilian de Jonge, Madlyn I. Frisard, James P. DeLany, D. Enette Larson-Meyer, Jennifer Rood, Tuong Nguyen, Corby K. Martin, Julia Volaufova, Marlene M. Most, Frank L. Greenway, Steven R. Smith, Walter A. Deutsch, Donald A. Williamson, Eric Ravussin for the Pennington CALERIE Team
JAMA. 2006; 295:1539-1548. [Abstract]

Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
Xueliang Du, Diane Edelstein, Silvana Obici, Ninon Higham, Ming-Hui Zou, and Michael Brownlee
J. Clin. Invest. 2006; 116:1071-1080. [Abstract]

Farnesoid X receptor is essential for normal glucose homeostasis

Ke Ma, Pradip K. Saha, Lawrence Chan, and David D. Moore
J. Clin. Invest. 2006; 116:1102-1109. [Abstract]

Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
Alessandro Pocai, Tony K.T. Lam, Silvana Obici, Roger Gutierrez-Juarez, Evan D. Muse, Arduino Arduini, and Luciano Rossetti
J. Clin. Invest. 2006; 116:1081-1091. [Abstract]