IRIG: Controversy on obesity gene in Science
01/16/2007 23:01
It was reported in Science (Reports, 14 April
2006, p. 279) about an
association between the INSIG2
gene variant rs7566605 and obesity
in four sample populations, under a recessive model.
The controversy about the association is reported in
the current issue of Science. Data from a couple
of labs does not support the association. See
below.
In Science Magazine
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Christian Dina, David Meyre, Chantal Samson, Jean Tichet, Michel Marre, Beatrice Jouret, Marie Aline Charles, Beverley Balkau, and Philippe Froguel (12 January 2007)
Science 315 (5809), 187b. [DOI: 10.1126/science.1129402]
| Abstract » | Full Text » | PDF »
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Ruth J. F. Loos, Inês Barroso, Stephen O'Rahilly, and Nicholas J. Wareham (12 January 2007)
Science 315 (5809), 187c. [DOI: 10.1126/science.1130012]
| Abstract » | Full Text » | PDF »
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Dieter Rosskopf, Alexa Bornhorst, Christian Rimmbach, Christian Schwahn, Alexander Kayser, Anne Krüger, Grietje Tessmann, Ingrid Geissler, Heyo K. Kroemer, and Henry Völzke (12 January 2007)
Science 315 (5809), 187d. [DOI: 10.1126/science.1130571]
| Abstract » | Full Text » | PDF »
REPORTS
A Common Genetic Variant Is Associated with Adult and Childhood Obesity
Alan Herbert, Norman P. Gerry, Matthew B. McQueen, Iris M. Heid, Arne Pfeufer, Thomas Illig, H.-Erich Wichmann, Thomas Meitinger, David Hunter, Frank B. Hu, Graham Colditz, Anke Hinney, Johannes Hebebrand, Kerstin Koberwitz, Xiaofeng Zhu, Richard Cooper, Kristin Ardlie, Helen Lyon, Joel N. Hirschhorn, Nan M. Laird, Marc E. Lenburg, Christoph Lange, and Michael F. Christman (14 April 2006)
Science 312 (5771), 279. [DOI: 10.1126/science.1124779]
| Abstract » | Full Text » | PDF » | Supporting Online Material »
------------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763-3163
E-mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
In Science Magazine
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Christian Dina, David Meyre, Chantal Samson, Jean Tichet, Michel Marre, Beatrice Jouret, Marie Aline Charles, Beverley Balkau, and Philippe Froguel (12 January 2007)
Science 315 (5809), 187b. [DOI: 10.1126/science.1129402]
| Abstract » | Full Text » | PDF »
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Ruth J. F. Loos, Inês Barroso, Stephen O'Rahilly, and Nicholas J. Wareham (12 January 2007)
Science 315 (5809), 187c. [DOI: 10.1126/science.1130012]
| Abstract » | Full Text » | PDF »
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Dieter Rosskopf, Alexa Bornhorst, Christian Rimmbach, Christian Schwahn, Alexander Kayser, Anne Krüger, Grietje Tessmann, Ingrid Geissler, Heyo K. Kroemer, and Henry Völzke (12 January 2007)
Science 315 (5809), 187d. [DOI: 10.1126/science.1130571]
| Abstract » | Full Text » | PDF »
REPORTS
A Common Genetic Variant Is Associated with Adult and Childhood Obesity
Alan Herbert, Norman P. Gerry, Matthew B. McQueen, Iris M. Heid, Arne Pfeufer, Thomas Illig, H.-Erich Wichmann, Thomas Meitinger, David Hunter, Frank B. Hu, Graham Colditz, Anke Hinney, Johannes Hebebrand, Kerstin Koberwitz, Xiaofeng Zhu, Richard Cooper, Kristin Ardlie, Helen Lyon, Joel N. Hirschhorn, Nan M. Laird, Marc E. Lenburg, Christoph Lange, and Michael F. Christman (14 April 2006)
Science 312 (5771), 279. [DOI: 10.1126/science.1124779]
| Abstract » | Full Text » | PDF » | Supporting Online Material »
------------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763-3163
E-mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
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