IRIG: Obestatin in "Science" and S6K in JCI IRIG: Obestatin in "Science" and S6K in JCI IRIG: Obestatin in "Science" and S6K in JCI IRIG: Obestatin in "Science" and S6K in JCI IRIG: Obestatin in "Science" and S6K in JCI
02/09/2007 08:26
Obestatin,
a peptide derived from the ghrelin precursor, has an
activity opposite to ghrelin for appetite. In the
action mechanism, obestatin was reported to activate
the orphan G protein–coupled receptor GPR39. This
activity of obestatin is under debate in
two technical comments in the current issue of
Science. Below is the titles and
links.
Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"
N. Chartrel, R. Alvear-Perez, J. Leprince, X. Iturrioz, A. Reaux-Le Goazigo, V. Audinot, P. Chomarat, F. Coge, O. Nosjean, M. Rodriguez, J. P. Galizzi, J. A. Boutin, H. Vaudry, and C. Llorens-Cortes
http://www.sciencemag.org/cgi/content/abstract/315/5813/766c?etoc
p. 766
Response to Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"
Jian V. Zhang, Cynthia Klein, Pei-Gen Ren, Stefan Kass, Luc Ver Donck, Dieder Moechars, and Aaron J. W. Hsueh
http://www.sciencemag.org/cgi/content/abstract/315/5813/766d?etoc
p. 766
S6K is a signaling enzyme in the insulin receptor pathway. S6K has been shown to induce IRS-1 serine phosphorylation (at Ser307 in mouse or Ser312 in human) for insulin resistance. S6K knockout mice are resistant to obesity and insulin resistance. In the current JCI, mice with increased S6K activity have "Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2". Below are titles and links of the paper and relative comment in JCI.
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2Olivier Le Bacquer, Emmanuel Petroulakis, Sabina Paglialunga, Francis Poulin, Denis Richard, Katherine Cianflone, and Nahum Sonenberg J. Clin. Invest. 2007; 117:387-396. [Abstract] [Full Text] [PDF]
A link between protein translation and body weightLiangyou Rui J. Clin. Invest. 2007; 117:310-313. [Abstract] [Full Text] [PDF]
By Jianping at PBRC
—--------------------------------------------------
Jianping Ye, MD Professor of Molecular Biology Pennington Biomedical Research Center Louisiana State University System 6400 Perkins Road Baton Rouge, LA 70808 Phone: (225) 763-3163 Fax: (225) 763-2525 E-mail: yej@pbrc.edu
Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"
N. Chartrel, R. Alvear-Perez, J. Leprince, X. Iturrioz, A. Reaux-Le Goazigo, V. Audinot, P. Chomarat, F. Coge, O. Nosjean, M. Rodriguez, J. P. Galizzi, J. A. Boutin, H. Vaudry, and C. Llorens-Cortes
http://www.sciencemag.org/cgi/content/abstract/315/5813/766c?etoc
p. 766
Response to Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"
Jian V. Zhang, Cynthia Klein, Pei-Gen Ren, Stefan Kass, Luc Ver Donck, Dieder Moechars, and Aaron J. W. Hsueh
http://www.sciencemag.org/cgi/content/abstract/315/5813/766d?etoc
p. 766
S6K is a signaling enzyme in the insulin receptor pathway. S6K has been shown to induce IRS-1 serine phosphorylation (at Ser307 in mouse or Ser312 in human) for insulin resistance. S6K knockout mice are resistant to obesity and insulin resistance. In the current JCI, mice with increased S6K activity have "Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2". Below are titles and links of the paper and relative comment in JCI.
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2Olivier Le Bacquer, Emmanuel Petroulakis, Sabina Paglialunga, Francis Poulin, Denis Richard, Katherine Cianflone, and Nahum Sonenberg J. Clin. Invest. 2007; 117:387-396. [Abstract] [Full Text] [PDF]
A link between protein translation and body weightLiangyou Rui J. Clin. Invest. 2007; 117:310-313. [Abstract] [Full Text] [PDF]
By Jianping at PBRC
—--------------------------------------------------
Jianping Ye, MD Professor of Molecular Biology Pennington Biomedical Research Center Louisiana State University System 6400 Perkins Road Baton Rouge, LA 70808 Phone: (225) 763-3163 Fax: (225) 763-2525 E-mail: yej@pbrc.edu
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