IRIG: Muscle insulin resistance
05/22/2007 07:58
Accumulation of
triglycerides in skeletal muscle was taken as an
indicator of muscle insulin resistance. However,
this idea was challenged by a reverse
association of TG and insulin resistance in the
trained athlete muscle. Increasing evidence suggests
that not TG, but intermediates of FFAs (DAG and
ceramide), are the problem in muscle for insulin
resistance. This concept is re-enforced by two new
studies in JCI as following.
In last e-mail, I provided a PDF file of my review that is not printable. Now, the printable file is attached. Thanks a lot for your interest in the printable file.
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance
Simon Schenk and Jeffrey F. Horowitz
published 17 May 2007, 10.1172/JCI30566 [Abstract] [PDF]
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistanceLi Liu, Yiying Zhang, Nancy Chen, Xiaojing Shi, Bonny Tsang, and Yi-Hao Yu published 17 May 2007, 10.1172/JCI30565 [Abstract] [PDF]
by Jianping at PBRC
-----------------------------------
Jianping Ye, MD Professor of Molecular Biology Pennington Biomedical Research Center Louisiana State University System 6400 Perkins Road Baton Rouge, LA 70808 Phone: (225) 763-3163 Fax: (225) 763-2525 E-mail: yej@pbrc.edu
In last e-mail, I provided a PDF file of my review that is not printable. Now, the printable file is attached. Thanks a lot for your interest in the printable file.
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance
Simon Schenk and Jeffrey F. Horowitz
published 17 May 2007, 10.1172/JCI30566 [Abstract] [PDF]
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistanceLi Liu, Yiying Zhang, Nancy Chen, Xiaojing Shi, Bonny Tsang, and Yi-Hao Yu published 17 May 2007, 10.1172/JCI30565 [Abstract] [PDF]
by Jianping at PBRC
-----------------------------------
Jianping Ye, MD Professor of Molecular Biology Pennington Biomedical Research Center Louisiana State University System 6400 Perkins Road Baton Rouge, LA 70808 Phone: (225) 763-3163 Fax: (225) 763-2525 E-mail: yej@pbrc.edu
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