Dec 2010
IRIG: Autophagy in 2010
12/21/2010 17:49
In 2008, we introduced a review article in Cell with
title “Autophagy in the Pathogenesis of Disease”
(Cell 2008;132:27-42). In 2009, autophagy were
reported to be required for adipogenesis and be
reduced in mouse liver under insulin resistance. This
year, the trend in autophagy/metabolism research
continues with more publications in the mainstream
including Nature, Science, Cell and Cell Metabolism.
Autophagy seems to be another hot topic after
cell apoptosis in the basic research in cell biology.
It is involved in pathogenesis of cancer, aging,
development, diabetes, obesity, and
cardiovascular diseases, et al. Autophagy is
inhibited by insulin and nutrient (amino acids). Its
reduction is expected in the presence of
hyperinsulinemia/insulin resistance in obesity. The
autophagy inhibition may be a new cellular link
between insulin resistance and other disorders in
type 2 diabetes. Below are some of the autophagy
papers in 2010 for your reference.
1. Behrends C, Sowa ME, Gygi SP, and Harper JW. Network organization of the human autophagy system. Nature 466: 68-76, 2010.
2. Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, and Chen Y-G. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol 12: 781-790, 2010.
3. Rabinowitz JD, and White E. Autophagy and metabolism. Science 330: 1344-1348, 2010.
4. Yang L, Li P, Fu S, Calay ES, and Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 11: 467-478, 2010.
5. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, and Lenardo MJ. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 2010.
6. Mizushima N, Yoshimori T, and Levine B. Methods in mammalian autophagy research. Cell 140: 313-326, 2010.
7. Tian Y, Li Z, Hu W, Ren H, Tian E, Zhao Y, Lu Q, Huang X, Yang P, Li X, Wang X, Kovacs AL, Yu L, and Zhang H. C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell 141: 1042-1055, 2010.
Merry Christmas!
By Jianping (Jim) at PBRC/LSU
---------------------------------------------------
Jianping Ye, M.D.
Professor of Molecular Biology
Antioxidant and Gene Regulation Lab
PBRC/LSU
E-mail: yej@pbrc.edu
Phone: (225) 763-3163
1. Behrends C, Sowa ME, Gygi SP, and Harper JW. Network organization of the human autophagy system. Nature 466: 68-76, 2010.
2. Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, and Chen Y-G. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol 12: 781-790, 2010.
3. Rabinowitz JD, and White E. Autophagy and metabolism. Science 330: 1344-1348, 2010.
4. Yang L, Li P, Fu S, Calay ES, and Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 11: 467-478, 2010.
5. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, and Lenardo MJ. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 2010.
6. Mizushima N, Yoshimori T, and Levine B. Methods in mammalian autophagy research. Cell 140: 313-326, 2010.
7. Tian Y, Li Z, Hu W, Ren H, Tian E, Zhao Y, Lu Q, Huang X, Yang P, Li X, Wang X, Kovacs AL, Yu L, and Zhang H. C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell 141: 1042-1055, 2010.
Merry Christmas!
By Jianping (Jim) at PBRC/LSU
---------------------------------------------------
Jianping Ye, M.D.
Professor of Molecular Biology
Antioxidant and Gene Regulation Lab
PBRC/LSU
E-mail: yej@pbrc.edu
Phone: (225) 763-3163
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