Jan 2011
IRIG: Type 2 diabetes at 11.3% in US adults now
01/29/2011 16:24
In today’s news at CDC website, new epidemiology data
is released for type 2 diabetes in US. It states that
“Diabetes affects 8.3 percent of Americans of all
ages, and
11.3 percent
of adults aged 20 and older, according to the
National Diabetes Fact Sheet for 2011. About 27
percent of those with diabetes—7 million Americans—do
not know they have the disease. Prediabetes affects
35 percent of adults aged 20 and
older.”
Please find detail at CDC website at this link: http://www.cdc.gov/media/releases/2011/p0126_diabetes.html
By Jim
--------------------------------------------
Jianping Ye, M.D.
Professor of Molecular Biology
Antioxidant and Gene Regulation Lab
PBRC/LSU
E-mail: yej@pbrc.edu
Phone: (225) 763-3163
Please find detail at CDC website at this link: http://www.cdc.gov/media/releases/2011/p0126_diabetes.html
By Jim
--------------------------------------------
Jianping Ye, M.D.
Professor of Molecular Biology
Antioxidant and Gene Regulation Lab
PBRC/LSU
E-mail: yej@pbrc.edu
Phone: (225) 763-3163
|
IRIG: Inflammation in Obesity: what is new?
01/17/2011 21:43
Obesity-associated
inflammation remains a hot area in the basic research
of obesity and diabetes. There are several excellent
review articles and original studies recently
published in the high profile journals on this topic
(listed below). These papers consistently
supports that inflammation involves in pathogenesis
of insulin resistance in obesity. In obesity,
inflammation and lipid disorder are associated
together. Which one is more important? Their
contribution to insulin resistance is hard to be
separated. This issue is addressed independently by
works from Shoelson’s lab and my lab using two
different mouse models. In Shoelson’s work,
inhibition of inflammation does not improve
insulin sensitivity in the absence of improvement in
lipid metabolism, which is done in lipodystrophy
mice. In our work, Inflammation does not cause
insulin resistance in the absence of lipid
accumulation in NF-kB Tg mice. The results
consistently suggest that inflammation is dependent
on lipotoxicity in the pathogenesis of insulin
resistance. Please read attached PDF files of the two
papers for detail.
Paper from Steven Shoelson
Paper from Jianping Ye
1. Olefsky JM, and Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72: 219-246, 2010.
2. Oh da Y, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, and Olefsky JM. GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects. Cell 142: 687-698, 2010.
3. Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, and Hotamisligil GS. Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell 140: 338-348, 2010.
4. Park EJ, Lee JH, Yu G-Y, He G, Ali SR, Holzer RG, Österreicher CH, Takahashi H, and Karin M. Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression. Cell 140: 197-208, 2010.
5. Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, and Dixit VD. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011.
6. Baker RG, Hayden MS, and Ghosh S. NF-kappaB, Inflammation, and Metabolic Disease. Cell Metab 13: 11-22, 2011.
Have a nice weekend,
Jim
-----------------------------------------
Jianping Ye, M.D.
Professor of Molecular Biology
Antioxidant and Gene Regulation Lab
PBRC/LSU
E-mail: yej@pbrc.edu
Phone: (225) 763-3163
Paper from Steven Shoelson
Paper from Jianping Ye
1. Olefsky JM, and Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72: 219-246, 2010.
2. Oh da Y, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, and Olefsky JM. GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects. Cell 142: 687-698, 2010.
3. Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, and Hotamisligil GS. Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell 140: 338-348, 2010.
4. Park EJ, Lee JH, Yu G-Y, He G, Ali SR, Holzer RG, Österreicher CH, Takahashi H, and Karin M. Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression. Cell 140: 197-208, 2010.
5. Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, and Dixit VD. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011.
6. Baker RG, Hayden MS, and Ghosh S. NF-kappaB, Inflammation, and Metabolic Disease. Cell Metab 13: 11-22, 2011.
Have a nice weekend,
Jim
-----------------------------------------
Jianping Ye, M.D.
Professor of Molecular Biology
Antioxidant and Gene Regulation Lab
PBRC/LSU
E-mail: yej@pbrc.edu
Phone: (225) 763-3163