IRIG: Hot topic in "Nature" - Obesity and Type 2 diabetes

12/15/2006 09:00
In the current issue of Nature, several review articles are published around obesity and type 2 diabetes to provide an update in the field of metabolic syndrom research. Additionally, two original studies are reported for identification of a new molecular mechanism controlling insulin signaling. Following is the related content of this issue.
 
By Jianping at PBRC  
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INSIGHT OF NATURE
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INTRODUCTION
Obesity and diabetes
Deepa Nath, Marie-Therese Heemels and Lesley Anson
10.1038/444839a
http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHwz0EB
 
REVIEW ARTICLE
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Steven E. Kahn, Rebecca L. Hull and Kristina M. Utzschneider
10.1038/nature05482
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHw10Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHw20Ex
 
Adipocytes as regulators of energy balance and glucose homeostasis
Evan D. Rosen and Bruce M. Spiegelman
10.1038/nature05483
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHw30Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHw40Ez
 
Gut hormones and the regulation of energy homeostasis
Kevin G. Murphy and Stephen R. Bloom
10.1038/nature05484
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHw50E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHw60E2
 
Inflammation and metabolic disorders
Gokhan S. Hotamisligil
10.1038/nature05485
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHw70E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHw80E4
 
Sirtuins as potential targets for metabolic syndrome
Leonard Guarente
10.1038/nature05486
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxA0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxB0EG
 
Mechanisms linking obesity with cardiovascular disease
Luc F. Van Gaal, Ilse L. Mertens and Christophe E. De Block
10.1038/nature05487
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxC0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxD0EI
 
Abdominal obesity and metabolic syndrome
Jean-Pierre Despres and Isabelle Lemieux
10.1038/nature05488
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxE0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxF0EK
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance
An inhibitor of SecinH3 is identified, and shows that treatment of mice with
this molecule induces hepatic insulin resistance, an early step in the
development of type 2 diabetes.
Markus Hafner et al.
10.1038/nature05415
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxe0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxf0Eq
 
The cytohesin Steppke is essential for insulin signalling in Drosophila
A complementary study to that of Famulock et al. shows that feeding SecinH3 to
flies inhibits steppke, a cytohesin, leading to growth defects and a block in
insulin signalling.
Bernhard Fuss, Thomas Becker, Ingo Zinke and Michael Hoch
10.1038/nature05412
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxg0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ebgD0SohGc0HjB0BHxh0Es


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Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763-3163
E-mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
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